Typhoid is a bacterial contamination that leads to a high fever, diarrhoea, and vomiting. It can be fatal and is affected by the bacteria Salmonella typhi. The typhoid fever is frequently caused owing to ingestion of contaminated food or water. Typhoid vaccines stop typhoid fever and offer protection against it. World Health Organization (WHO) has suggested three typhoid vaccines for use, which contain capsular polysaccharide vaccines, live attenuated vaccine, and conjugate vaccine. Conjugate vaccine (Vi-TT) contains Vi antigen that is combined to a carrier protein. In this vaccine, polysaccharide is involved to a more complex protein. In infants, these cells can efficiently develop immune protection against pathogens. Polysaccharides are weaker by itself, though, by binding to a protein carrier, polysaccharides can arrive into important parts of the immune system with comfort and can get more effortlessly noticed by the immunity system then the system can develop antibodies itself. These are the main benefits of conjugate vaccines over other vaccine type. There are presently only two conjugate vaccines available in the market i.e., Peda-Typh manufactured by Bio-Med Pvt. Ltd. and Typbar TCV produced by Bharat Biotech. Both the vaccines are existing in private market (i.e. India).
Rising prevalence of typhoid is anticipated to drive growth of the global typhoid conjugate vaccines (TCV) market over the forecasted period. As per the World Health Organization report published on January 2018, around 11–20 million people fall sick owing to typhoid and nearly 128,000 to 161,000 people die due to it each year, worldwide. As per the National Center for Biotechnology Information (NCBI), 2017, typhoid and paratyphoid fever occurrence rates vary in several nations from 6/100,000 to 1,173/100,000 persons every year. International Health Metrics and Evaluation (IHME) estimated that in 2016, there were about 12 million cases of typhoid fever causing in around 130,000 deaths, worldwide. However, as per the European Centre for Disease Prevention and Control (ECDC), 2016, typhoid and paratyphoid fever is comparatively a rare disease in the (EU/EEA) The European Economic, mostly acquired while wandering to nations outside of the EU/EEA, mostly in South Asia, India, Pakistan, and Bangladesh, which are the top three nations with travel-associated typhoid and paratyphoid fever cases.
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The global demand for TCV vaccines market was predicted to be about USD 330 million in 2022, and by the end of 2031, existing and expected developments would hit valuations of around USD 890 million. The industry players and analysts predict the global TCV vaccines market growth of around 12.0% in terms of CAGR. During the forthcoming years, rising prevalence of typhoid and growing research, surging public initiatives for endorsing and progressing the development of ground-breaking products are anticipated to upsurge the market growth. However, restrictions related to available vaccines, reoccurrence of contrary events after immunization are the factors hindering the growth of the market in the forecasted period.
Some of the leading and top TCV vaccines companies in the global TCV vaccines market include GlaxoSmithKline PLC, Sanofi SA, Bharat Biotech, PT BIO FARMA, Shanghai Institute of Biological Products Co., Ltd., Prokarium, Bio-Med Pvt. Ltd., PaxVax, Inc. among others. The leading five players such as GlaxoSmithKline PLC, Prokarium, Sanofi SA, Bharat Biotech, Bio-Med Pvt. Ltd. hold around 70% market share of the global TCV vaccines market.
On the basis of type, the global TCV vaccines market can be segmented into Ty21a (Vivotif), ViCPS (Typhim Vi), Vi-TT (Peda-typhTM), Typbar TCV, with the ‘ViCPS (Typhim Vi)’ category having the leading market share of about 50 percent, closely followed by the “Typbar TCV” category at about 20 percent of the global TCV vaccines market share.
On the basis of distribution channel, the market can be segmented into public and private. In terms of geography, North America region held the leading market share of around 30% among other regions such as Asia Pacific, Europe, Latin America, and Middle East & Africa in the global TCV vaccines market.
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