Urea cycle disorder (UCD) is an association of rare genomic illness which distresses roughly 3,000 - 7000 people each year in the U.S. UCD is introduced by a modification in genes, which reasons shortage of any of the six vital enzymes necessary for the urea cycle. Excess ammonia is transformed into urea in the mitochondria of liver cells by the urea cycle, also called as the ornithine cycle. The urea is formed, then it arrives the bloodstream, goes over the kidneys' filtering process, and finally it is reduced in the urine.
The increasing prevalence of is anticipated to upsurge the demand for treatment preferences for urea cycle disorders (UCD), which is estimated to drive the growth of global urea cycle disorders treatment market throughout the forecasted period. As per the Urea Cycle Disorders Consortium (UCDC), a section of the Rare Diseases Clinical Research Network (RDCRN), united prevalence of urea cycle disorders is nearby 1 in 30,000 people in the U.S in 2017.
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The global demand for urea cycle disorders treatment market was predicted to be about USD 1,450 million in 2022, and by the end of 2031, existing and expected developments would hit valuations of around USD 1,850 million. The industry players and analysts predict the global Urea cycle disorders treatment market growth of around 3.5% in terms of CAGR. During the upcoming years, the increasing prevalence of urea cycle disorders and the growing number of pipeline products. Product approvals, launches, and strategic initiatives by important market players are anticipated to contribute to market growth. Furthermore, research and development studies underlining the genetic description of urea cycle disorders will benefit market players align their product development supporting to market growth. On the other hand, the high cost of therapeutics can be a restraint in the growth of this market.
Some of the leading and top urea cycle disorders treatment companies in the global urea cycle disorders treatment market include Bausch Health Companies Inc., Recordati Rare Diseases, Eurocept Pharmaceuticals Holding (Lucane Pharma SA), Acer Therapeutics, Ultragenyx Pharmaceutical, Aeglea BioTherapeutics, Arcturus Therapeutics, Inc., Orpharma Pty Ltd., Selecta Biosciences, Inc., Abbott Laboratories, and Mead Johnson & Company, LLC among others. The leading five players such as Bausch Health Companies Inc., Recordati Rare Diseases, Eurocept Pharmaceuticals Holding (Lucane Pharma SA), Acer Therapeutics, and Ultragenyx Pharmaceutical hold about 40% market share of the global urea cycle disorders treatment market.
On the basis of enzyme deficiency type, the global urea cycle disorders treatment market can be segmented into ornithine transcarbamylas (OTC), argininosuccinate synthetase (citrullinemia) (AS), arginase (AG), argininosuccinate lyase (AL), carbamoyl phosphate synthase (CPS1), and N-acetylglutamate synthase (NAGS) with the ‘ornithine transcarbamylas (OTC)’ category having the leading market share of about 30 percent, closely followed by the “argininosuccinate synthetase (citrullinemia) (AS)” category at about 20 percent of the global urea cycle disorders treatment market share. On the basis of treatment type, the global urea cycle disorders treatment market can be segmented into amino acid supplements, sodium phenylbutyrate, glycerol phenylbutyrate, sodium benzoate, and others. On the basis of route of administration, the global urea cycle disorders treatment market can be segmented into oral and injectable. In terms of regional analysis, North America region detained the prominent market share of around 40% among other regions such as Asia Pacific, Europe, Latin America, and Middle East & Africa in the global urea cycle disorders treatment market.
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