Gaucher Disease Market Analysis By Disease Type(Type 1 Gaucher disease, Type 2 Gaucher disease, Type 3 Gaucher disease), By Therapy Type(Enzyme Replacement Therapy (ERT), Substrate Reduction Therapy (SRT)), By End Users(Hospitals, Specialty Clinics, Homecare), By Distribution Channel(Hospitals, Retail Pharmacies, Online Pharmacies) & Forecast 2024-2035
- PUBLISHED ON
- 9/1/2022
- NO OF PAGES
- 219
- CATEGORY
- Healthcare & Life Sciences
The market for Gaucher disease was estimated at USD 980.0 million in 2021, and it is anticipated to grow at a CAGR of 8.5% to reach around USD 1,800.0 million in 2029.
The rising prevalence of Gaucher disease, increasing awareness about Gaucher disease, and upsurge in the number of approved therapies for the treatment of Gaucher disease. Even it is the most prevalent lysosomal storage disorder, Gaucher disease is a rare disorder with an average prevalence of 1 in 100,000 individuals. However, some ethnic races such as Ashkenazi Jews are more inclined to this disorder. Ashkenazi Jews have an average disease prevalence of 1 in 100,000 individuals. However, the high cost related with the treatment of Gaucher's disease may restrain the growth of this market during the forecast period.
Increasing prevalence of Gaucher disease backed by the growing rate of inheritance of the disease, accessory initiatives by governments round the world, and growing awareness concerning the disease is expected to be among the major factors to propel the expansion of the market. The increase of the Gaucher disease market will be additional ascribed to the rising investments and expenditure for the R&D activities to incessantly refer additional possible solutions for the treatment. Furthermore, increasing number of government initiatives to spread awareness and growing adoption rate of early diagnosis will result in the expansion of Gaucher disease market. On addition to this, increasing disposable income and rising need for better disease treatment options will boost the market's growth rate.
The global market for Gaucher disease is growing owing due to the outbreak of the COVID-19. A huge demand for Gaucher disease has been created by the increase in patients around the world, the large number of vaccine trials and development, and the COVID-19 vaccination programmes. Hence, the COVID-19 pandemic increased the market size for Gaucher disease in 2021.
Disease Type Insights
The type 1 disease segment is expected to carry the largest market size by growing at a major CAGR over the forecast amount. The common symptoms of type 1 disease include embody spleen and liver enlargement, bone issues, and fatigue. the expansion of the phase will be related to the rising variety of individuals plagued by type-1 disease across the globe. As sourced from the National Gaucher Foundation, close to 95% of total cases area unit stricken by sort one Gaucher malady in western countries.
Some of the drugs received approvals recently for the Gaucher disease treatment. For instance, U.S. Food and Drug Administration (FDA) has approved multiple drugs in past several years for the treatment of disease. In 2012, Elelyso and in 2014, Cerdelga was permitted by FDA for type 1 Gaucher disease. In 2010, FDA approved Vpriv, an enzyme replacement therapy (ERT), for type 1 Gaucher disease. These drugs offer range of options based on their requests, in turn is anticipated to fuel the growth of the market.
Type 2 and 3 are rare types of this disease. Both these conditions are neuronopathic, causing CNS complications throughout the disease course. Infants with type 2 GD rarely survive over two years, due to lack of treatment and severity of disease progression.
Other rare types of the disease include perinatal lethal form and cardiac form. The perinatal lethal form is the most adverse type of the disease, leading to life-threatening complications in infants or fetuses. Cardiac form affects the heart, generally, causing calcification of heart valves.
Therapy Type Insights
The enzyme replacement therapy market is anticipated to grow at a substantial rate during the forecast period due to increasing cases of Gaucher disease worldwide. Around 10-20 cases per million are reported yearly in the U.S., however approximately 100 cases per million are reported in Europe and Asia.
However, ERT is predicted to lose shares in the coming years due to the high cost of therapy and troublesome dosing schedule. Furthermore, ERT is regularly used for type 1 and type 3 to address problems unrelated to CNS as replacement enzymes cannot enter blood brain barrier. The treatment landscape is observing a gradual shift towards substrate replacement therapy (SRT), controlled by Cerdelga and Zavesca.
Region Insights
North America is predicted to dominant the Gaucher disease market due to growing investigations for the development of new medication. In 2016, the human from National Institutes of Health researchers collaborated with National Institute of medical specialty Disorders and Stroke (NINDS) and therefore the National Center for Advancing Travel Sciences (NCATS). Researchers known a brand new molecule that shows promising approach for treatment of the rare Gaucher disease.
Europe is predicted to be the second largest marketplace for Gaucher malady treatment thanks to the initiative taken by European organizations to unfold awareness concerning Gaucher malady among the population. for example, in 2014, European Gaucher Alliance launched Gaucher Awareness Day reaching to unfold awareness concerning this rare malady among the European population.
Key Companies Insights
Key players are aiming on their technological partnerships, collaborations, and merger & acquisitions strategies to attain a competitive edge and expand their product portfolio & business footprint. The ongoing Covid-19 pandemic hindered the healthcare systems across the globe and drove market players to innovate products for unexploited opportunities.
Some of the key players operating in the global Gaucher disease market include:
• Genzyme Corporation (Sanofi)
• Pfizer, Inc.
• Shire Human Genetics Therapies, Inc.
• Actelion Pharmaceuticals Ltd. (Johnson & Johnson)
• AVROBIO, Inc.
• Bristol-Myers Squibb Company
• PerkinElmer Inc.
• Amicus Therapeutics, Inc.
• Moderna, Inc.
• Greenovation Biotech GmbH
• Biomarin
• Takeda Pharmaceutical Company Limited
• AstraZeneca PLC
• Eli Lilly and Company
• Other players
There are several drugs in pipeline of companies such as Lixte Biotechnology Holdings Inc., JCR Pharmaceuticals Co Ltd., Pharming Group NV, and Orphazyme ApS
Some of the Recent Developments:
• In 2017, Janssen acquired Actelion to add complementary therapeutics and promising late-stage pipeline candidates to its portfolio.
• In 2015, Protalix sold worldwide rights of Elelyso to Pfizer.
• In 2012, Protalix entered into a licensing deal with Pfizer in 2009 for clinical development and commercialization of Elelyso.
Segments
By Disease Type
• Type 1 Gaucher disease
• Type 2 Gaucher disease
• Type 3 Gaucher disease
By Therapy Type
• Enzyme Replacement Therapy (ERT)
• Substrate Reduction Therapy (SRT)
By End Users
• Hospitals
• Specialty Clinics
• Homecare
• Others
By Distribution Channel
• Hospitals
• Retail Pharmacies
• Online Pharmacies
By Geography
• North America
o U.S.
o Canada
o Mexico
• Europe
o U.K.
o Germany
o France
o Italy
o Spain
o Russia
• Asia-Pacific
o Japan
o China
o India
o Australia
o South Korea
o ASEAN
• Latin America
o Brazil
o Argentina
o Colombia
• MEA
o South Africa
o Saudi Arabia
o UAE
o Egypt
Frequently Asked Questions
• What is the market size and growth projections?
• What is the market size and growth projection for each of the market segments and sub-segments across Countries & Regions?
• What are the top performing segments, and countries / regions of each of the markets?
• What is the market size and growth rate across key countries / regions?
• How big is the global & regional market in terms of revenue and volume?
• How far market will grow in forecast period in terms of revenue and volume?
• What factors will influence demand and supply trends across each markets during the forecast period?
• What are the technology trends shaping various markets?
• Which country / region has more opportunities?
• What is the COVID-19 impact on the market and how long will it take to recover?
• Who are the key competitors of market Players?
• What are the market share (%) of Key Players?
• What are the Merger & Acquisition, New Product Launch, Recent Development within each of the Markets?
• What are PEST analysis, Ecosystem Analysis, Porter's Five Forecast Analysis, Ansoff Matrix, and SWOT Analysis among other analyses for diverse markets?
Historic Year: 2016-2022
Forecast: 2024-2035
1 Gaucher Disease Market Definition and Overview
1.1 Objectives of the Study
1.2 Overview of Gaucher Disease
1.3 Gaucher Disease Market Scope and Market Size Estimation
1.4 Market Segmentation
1.4.1 Types of Gaucher Disease
1.4.2 Applications of Gaucher Disease
1.5 Market Exchange Rate
2 Research Method and Logic
2.1 Methodology
2.2 Research Data Source
3 Market Competition Analysis
3.1 Sanofi Market Performance Analysis
3.1.1 Sanofi Basic Information
3.1.2 Product and Service Analysis
3.1.3 Strategies for Company to Deal with the Impact of COVID-19
3.1.4 Sanofi Sales, Value, Price, Gross Margin 2016-2021
3.2 ISU ABXIS Market Performance Analysis
3.2.1 ISU ABXIS Basic Information
3.2.2 Product and Service Analysis
3.2.3 Strategies for Company to Deal with the Impact of COVID-19
3.2.4 ISU ABXIS Sales, Value, Price, Gross Margin 2016-2021
3.3 Shire Market Performance Analysis
3.3.1 Shire Basic Information
3.3.2 Product and Service Analysis
3.3.3 Strategies for Company to Deal with the Impact of COVID-19
3.3.4 Shire Sales, Value, Price, Gross Margin 2016-2021
3.4 Pfizer (Protalix) Market Performance Analysis
3.4.1 Pfizer (Protalix) Basic Information
3.4.2 Product and Service Analysis
3.4.3 Strategies for Company to Deal with the Impact of COVID-19
3.4.4 Pfizer (Protalix) Sales, Value, Price, Gross Margin 2016-2021
3.5 Actelion Pharma Market Performance Analysis
3.5.1 Actelion Pharma Basic Information
3.5.2 Product and Service Analysis
3.5.3 Strategies for Company to Deal with the Impact of COVID-19
3.5.4 Actelion Pharma Sales, Value, Price, Gross Margin 2016-2021
4 Market Segment by Type, Historical Data and Market Forecasts
4.1 Global Gaucher Disease Production and Value by Type
4.1.1 Global Gaucher Disease Production by Type 2016-2021
4.1.2 Global Gaucher Disease Market Value by Type 2016-2021
4.2 Global Gaucher Disease Market Production, Value and Growth Rate by Type 2016-2021
4.2.1 Substrate Reduction Therapy Market Production, Value and Growth Rate
4.2.2 Enzyme Replacement Therapy Market Production, Value and Growth Rate
4.3 Global Gaucher Disease Production and Value Forecast by Type
4.3.1 Global Gaucher Disease Production Forecast by Type 2021-2026
4.3.2 Global Gaucher Disease Market Value Forecast by Type 2021-2026
4.4 Global Gaucher Disease Market Production, Value and Growth Rate by Type Forecast 2021-2026
4.4.1 Substrate Reduction Therapy Market Production, Value and Growth Rate Forecast
4.4.2 Enzyme Replacement Therapy Market Production, Value and Growth Rate Forecast
5 Market Segment by Application, Historical Data and Market Forecasts
5.1 Global Gaucher Disease Consumption and Value by Application
5.1.1 Global Gaucher Disease Consumption by Application 2016-2021
5.1.2 Global Gaucher Disease Market Value by Application 2016-2021
5.2 Global Gaucher Disease Market Consumption, Value and Growth Rate by Application 2016-2021
5.2.1 Neuronopathic Gaucher Disease Market Consumption, Value and Growth Rate
5.2.2 Non-neuronopathic Gaucher Disease Market Consumption, Value and Growth Rate
5.3 Global Gaucher Disease Consumption and Value Forecast by Application
5.3.1 Global Gaucher Disease Consumption Forecast by Application 2021-2026
5.3.2 Global Gaucher Disease Market Value Forecast by Application 2021-2026
5.4 Global Gaucher Disease Market Consumption, Value and Growth Rate by Application Forecast 2021-2026
5.4.1 Neuronopathic Gaucher Disease Market Consumption, Value and Growth Rate Forecast
5.4.2 Non-neuronopathic Gaucher Disease Market Consumption, Value and Growth Rate Forecast
6 Global Gaucher Disease by Region, Historical Data and Market Forecasts
6.1 Global Gaucher Disease Sales by Region 2016-2021
6.2 Global Gaucher Disease Market Value by Region 2016-2021
6.3 Global Gaucher Disease Market Sales, Value and Growth Rate by Region 2016-2021
6.3.1 North America
6.3.2 Europe
6.3.3 Asia Pacific
6.3.4 South America
6.3.5 Middle East and Africa
6.4 Global Gaucher Disease Sales Forecast by Region 2021-2026
6.5 Global Gaucher Disease Market Value Forecast by Region 2021-2026
6.6 Global Gaucher Disease Market Sales, Value and Growth Rate Forecast by Region 2021-2026
6.6.1 North America
6.6.2 Europe
6.6.3 Asia Pacific
6.6.4 South America
6.6.5 Middle East and Africa
7 United State Market Size Analysis 2016-2026
7.1 United State Gaucher Disease Value and Market Growth 2016-2021
7.2 United State Gaucher Disease Sales and Market Growth 2016-2021
7.3 United State Gaucher Disease Market Value Forecast 2021-2026
8 Canada Market Size Analysis 2016-2026
8.1 Canada Gaucher Disease Value and Market Growth 2016-2021
8.2 Canada Gaucher Disease Sales and Market Growth 2016-2021
8.3 Canada Gaucher Disease Market Value Forecast 2021-2026
9 Germany Market Size Analysis 2016-2026
9.1 Germany Gaucher Disease Value and Market Growth 2016-2021
9.2 Germany Gaucher Disease Sales and Market Growth 2016-2021
9.3 Germany Gaucher Disease Market Value Forecast 2021-2026
10 UK Market Size Analysis 2016-2026
10.1 UK Gaucher Disease Value and Market Growth 2016-2021
10.2 UK Gaucher Disease Sales and Market Growth 2016-2021
10.3 UK Gaucher Disease Market Value Forecast 2021-2026
11 France Market Size Analysis 2016-2026
11.1 France Gaucher Disease Value and Market Growth 2016-2021
11.2 France Gaucher Disease Sales and Market Growth 2016-2021
11.3 France Gaucher Disease Market Value Forecast 2021-2026
12 Italy Market Size Analysis 2016-2026
12.1 Italy Gaucher Disease Value and Market Growth 2016-2021
12.2 Italy Gaucher Disease Sales and Market Growth 2016-2021
12.3 Italy Gaucher Disease Market Value Forecast 2021-2026
13 Spain Market Size Analysis 2016-2026
13.1 Spain Gaucher Disease Value and Market Growth 2016-2021
13.2 Spain Gaucher Disease Sales and Market Growth 2016-2021
13.3 Spain Gaucher Disease Market Value Forecast 2021-2026
14 Russia Market Size Analysis 2016-2026
14.1 Russia Gaucher Disease Value and Market Growth 2016-2021
14.2 Russia Gaucher Disease Sales and Market Growth 2016-2021
14.3 Russia Gaucher Disease Market Value Forecast 2021-2026
15 China Market Size Analysis 2016-2026
15.1 China Gaucher Disease Value and Market Growth 2016-2021
15.2 China Gaucher Disease Sales and Market Growth 2016-2021
15.3 China Gaucher Disease Market Value Forecast 2021-2026
16 Japan Market Size Analysis 2016-2026
16.1 Japan Gaucher Disease Value and Market Growth 2016-2021
16.2 Japan Gaucher Disease Sales and Market Growth 2016-2021
16.3 Japan Gaucher Disease Market Value Forecast 2021-2026
17 South Korea Market Size Analysis 2016-2026
17.1 South Korea Gaucher Disease Value and Market Growth 2016-2021
17.2 South Korea Gaucher Disease Sales and Market Growth 2016-2021
17.3 South Korea Gaucher Disease Market Value Forecast 2021-2026
18 Australia Market Size Analysis 2016-2026
18.1 Australia Gaucher Disease Value and Market Growth 2016-2021
18.2 Australia Gaucher Disease Sales and Market Growth 2016-2021
18.3 Australia Gaucher Disease Market Value Forecast 2021-2026
19 Thailand Market Size Analysis 2016-2026
19.1 Thailand Gaucher Disease Value and Market Growth 2016-2021
19.2 Thailand Gaucher Disease Sales and Market Growth 2016-2021
19.3 Thailand Gaucher Disease Market Value Forecast 2021-2026
20 Brazil Market Size Analysis 2016-2026
20.1 Brazil Gaucher Disease Value and Market Growth 2016-2021
20.2 Brazil Gaucher Disease Sales and Market Growth 2016-2021
20.3 Brazil Gaucher Disease Market Value Forecast 2021-2026
21 Argentina Market Size Analysis 2016-2026
21.1 Argentina Gaucher Disease Value and Market Growth 2016-2021
21.2 Argentina Gaucher Disease Sales and Market Growth 2016-2021
21.3 Argentina Gaucher Disease Market Value Forecast 2021-2026
22 Chile Market Size Analysis 2016-2026
22.1 Chile Gaucher Disease Value and Market Growth 2016-2021
22.2 Chile Gaucher Disease Sales and Market Growth 2016-2021
22.3 Chile Gaucher Disease Market Value Forecast 2021-2026
23 South Africa Market Size Analysis 2016-2026
23.1 South Africa Gaucher Disease Value and Market Growth 2016-2021
23.2 South Africa Gaucher Disease Sales and Market Growth 2016-2021
23.3 South Africa Gaucher Disease Market Value Forecast 2021-2026
24 Egypt Market Size Analysis 2016-2026
24.1 Egypt Gaucher Disease Value and Market Growth 2016-2021
24.2 Egypt Gaucher Disease Sales and Market Growth 2016-2021
24.3 Egypt Gaucher Disease Market Value Forecast 2021-2026
25 UAE Market Size Analysis 2016-2026
25.1 UAE Gaucher Disease Value and Market Growth 2016-2021
25.2 UAE Gaucher Disease Sales and Market Growth 2016-2021
25.3 UAE Gaucher Disease Market Value Forecast 2021-2026
26 Saudi Arabia Market Size Analysis 2016-2026
26.1 Saudi Arabia Gaucher Disease Value and Market Growth 2016-2021
26.2 Saudi Arabia Gaucher Disease Sales and Market Growth 2016-2021
26.3 Saudi Arabia Gaucher Disease Market Value Forecast 2021-2026
27 Market Dynamic Analysis and Development Suggestions
27.1 Market Drivers
27.2 Market Development Constraints
27.3 PEST Analysis
27.3.1 Political Factors
27.3.2 Economic Factors
27.3.3 Social Factors
27.3.4 Technological Factors
27.4 Industry Trends Under COVID-19
27.4.1 Risk Assessment on COVID-19
27.4.2 Assessment of the Overall Impact of COVID-19 on the Industry
27.4.3 Pre COVID-19 and Post COVID-19 Market Scenario
27.5 Market Entry Strategy Analysis
27.5.1 Market Definition
27.5.2 Client
27.5.3 Distribution Model
27.5.4 Product Messaging and Positioning
27.5.5 Price
27.6 Advice on Entering the Market
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